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4F-MPH is a new research chemical in the stimulant family with an IUPAC name methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate. The chemical formula for 4F-MPH is C14H18FNO2 and it has a molecular weight of 251.30. The CAS number is 1354631-336. The chemical is so new on the market we must look research performed on its analog with is 4-MPH.
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The US Environmental Protection Agency’s EPISuite reported that analog has a 281.69 boiling point, 67.79 melting point, and 0.00203 vapor pressure estimations. The report also revealed that the chemical is water soluble at 25 deg C (mg/L): 3.073e+004.
4F-MPH is the 4-Fluro analogue of Methylpheindate and produces very similar results to its parent compound.
4-Fluoromethylphenidate was studied further along with other analogues of (±)-threo-methylphenidate (TMP) to assess their potential as anti-cocaine medications. 4F-MPH was reported as having an ED50 mg/kg of 0.26 (0.180.36), regarding its efficacy as a substitute for cocaine, and a relative potency of 3.33 compared to methylphenidate for the same purpose.
Another study found that in the threo-isomers of methylphenidate, the meta and para-substituted compounds with electron-withdrawing substituents tended to have increased binding potency. 4F-MPH was reported as having the following values: [3H]WIN 35428 binding of 35.0 ± 3.0 (2) and [3H]dopamine 142 ± 2.0 (2).
EFFECT AND DOSAGE
Anecdotal reports suggest that 4F-MPH is considerably more potent with fewer uncomfortable side effects such as anxiety, muscle spasms and compulsive redosing. This perhaps owes to the fact that it has been shown to act as a higher efficiency dopamine re-uptake inhibitor than the parent compound Methylphenidate.
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